报告题目🤱🏿：The Expanding Role of Lipid Droplets in Neurodegenerative Diseases报告人💧👩🏿💻：Mollereau✡️，里昂高等师范学校教授
主持人：翁杰敏 教授
报告时间：2019年4月17日 13:30（周三下午）报告地点：天美娱乐534报告厅
报告人简介：
Bertrand MOLLEREAU；Professor ENS、Professor at Institut Universitaire de France；Head of the Apoptosis and Neurogenetics Lab、LBMC-CNRS
Education
-University Paris Denis Diderot, France. HDR: French habilitation to supervize research. 2005-2006.
-University of Paris XI, Orsay, France. Ph.D. in Sciences (1993 to 1997)
Employment
-Institut Universitaire de France. Senior member (2017- to present)
-Ecole Normale Supérieure de Lyon, France: Head of Biology Department (2010 to 2013)
-Ecole Normale Supérieure de Lyon: Professor and Group leader at LBMC (2006 to present).
-The Rockefeller University, New York, USA. Research Assistant Professor, Principal Investigator. (2001 to 2006)
-The Rockefeller University, New York, USA. Post doctoral fellow, Pr Claude Desplan Laboratory
报告内容👙：
Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in brain disorders such as Alzheimer’s and Parkinson’s diseases. Lipid storage organelles (lipid droplets, LDs), accumulate in many cell types in response to stress, and it is now clear that LDs function not only as lipid stores but also as dynamic regulators of the stress response.However, whether these LD are always protective or can also be deleterious to the cell is matter of debate. We recently showed that dFatp (Drosophila fatty acid transport protein) is required and sufficient LD formation in retinal pigment cells (RPCs) and that FATP-mediated LD formation in RPCs promotes neuronal homeostasis (Van Den Brink et al. 2018). Furthermore, we used a Drosophila expressing alpha-synuclein as model of Parkinson’s disease (PD) in which we observed a neuronal accumulation of LD in Drosophila. During the seminar, I will discuss the mechanisms leading to LD accumulation and its pathological relevance in neurodegeneration.
