报告题目🦘：Systematic analysis of Th17 network reveals novel IL-23 signaling circuits
报 告 人：Chuan Wu, Postdoctoral fellow in Dr. Vijay Kuchroo’s lab, Dep. Neurology, Brigham and Women’s Hospital, Harvard Medical School, USA
主 持 人：赖玉平  教授
报告时间⛹🏽‍♂️🧝🏿：11月28日 13:30（周三）
报告地点：闵行生科院534报告厅
报告人简介✹👂🏽：Postdoctoral fellow in Dr. Vijay Kuchroo’s lab, Dep. Neurology, Brigham and Women’s Hospital, Harvard Medical School, USA
报告内容简介👷🏿‍♂️🙇🏼‍♀️：We used unbiased transcriptional profiling of developing Th17 cells to construct a model of their signaling network and identify major nodes that regulate Th17 development. We identified serum glucocorticoid kinase-1 (SGK1), as an essential node downstream of IL-23 signaling, critical for regulating IL-23R expression and for stabilizing Th17 cell phenotype.