报告题目： The cerebro-cerebellar loops: a network for sensorimotor tuning

报告人🚭：Clément Léna, Director of researcher at the Institute of Biology, école Normale Supérieure Paris.

主持人🌘：翁杰敏 教授

报告时间：2017年4月5日 13:30-15:00

报告地点：闵行生科院534报告厅

主办单位👨🏻‍⚕️：天美娱乐，科技处

 

报告人简介：After studying physics and then molecular and cellular neurophysiology at the école Normale Supérieure, Clément Léna conducted a thesis on the neurophysiological properties of nicotinic receptors of the central nervous system, under the direction of Jean-Pierre Changeux at the Institut Pasteur. In particular, he showed a direct action on the nerve endings of nicotine, studied its mechanisms, and contributed to the molecular identification of the different types of nicotinic receptors present in the mammalian brain. He then learned in vivo neurophysiology in the Matt Wilson laboratory at the Massachusetts Institute of Technology by studying limbic neural dynamics after emotional learning. On his return to France, he studied the aminergic regulation of states of vigilance and the existence of a postnatal critical period for the tuning of these regulations as well as those of the emotional system. In parallel, he developed the study of the population dynamics in the microcircuit of the cortex cerebellar in vivo. More recently, he has demonstrated the existence of functional olivo-cerebellar loops and cerebello-cortical loops. Clément Léna is an INSERM research director and leader of the Neurophysiology of Brain Circuits at the Ecole Normale Superieure in Paris.

 

报告摘要🙉：Preparing and executing action requires large portions of the brain; in the cortex, the frontal lobe hosts most of the cortical areas involved in these tasks. These cortical areas are assisted by two specific subcortical structures: the basal ganglia and the cerebellum. So far, the contribution of the cerebellum has been far less studied than the one of the basal ganglia. The main goal of our group is to understand better this contribution of the cerebellum to the preparation and execution of action.

The cerebellum contains more than half of the neurons in the brain and it is one of the largest cerebral structures. It has been compared to an adaptive filter, able to finely tune the actions of the body to the environment. The operations performed in its circuit have been analyzed for elementary reflexes (eyeblink conditioning, vestibulo-ocular reflex, saccade adaptation, etc…). Still, the largest part of the cerebellum is engaged in a dialog with the major anterior brain structures (cortex, basal ganglia, limbic system). Moreover, clinical evidence indicates that this dialog is disrupted in many neurological diseases and that the cerebellum may be a target for corrective treatments.

In this presentation, Dr. Léna will discuss the nature and the function of the reciprocal communication between the cerebellum and the forebrain, approached help to anatomy tracing, cellular physiology and network activity in the circuits linking the cerebellum and the cortex in normal and pathological conditions and the impact of modulations by opto- and pharmaco-genetics on motor function and learning.